Fang-Yen Laboratory

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Primary Research Articles

  1. A. Fouad, S. Teng, J. Mark, A. Liu, P. Alvarez-Illera, H. Ji, A. Du, P. Bhirgoo, E. Cornblath, A. Guan, and C. Fang-Yen, “Distributed rhythm generators underlie Caenorhabditis elegans forward locomotion” eLife (in press)
  2. S. Gao, S. Guan, A. D. Fouad, J. Meng, Y. Huang, Y. Li, S. Alcaire, W. Hung, T. Kawano, Y. Lu, Y. Qi, Y. Jin, M. Alkema, C. Fang-Yen, M. Zhen, “Excitatory Motor Neurons are Local Oscillators for Reverse Locomotion", eLife 6: e299915 (2017)
  3. P. D. McClanahan, J. H. Xu, and C. Fang-Yen, “Comparing Caenorhabditis elegans gentle and harsh touch response behavior using a multiplexed hydraulic microfluidic device”  Integrative Biology 9, 800-809 (2017)  [ cover image ]
  4. M. A. Churgin, R. J. McCloskey, E. Peters, and C. Fang-Yen, “Antagonistic serotonergic and octopaminergic neural circuits mediate food-dependent locomotory behavior in Caenorhabditis elegans Journal of Neuroscience 37, 7811-7823 (2017)
  5. M. A. Churgin, S. Jung, C. C. Yu, X. Chen, D. M. Raizen, and C. Fang-Yen, “Longitudinal imaging of Caenorhabditis elegans in a microfabricated device reveals variation in behavioral decline during aging” eLife 6:e26652 (2017)
  6. A. Fouad, S. Pu, S. Teng, J. Mark, M. Fu, K. Zhang, J. Huang, D. M. Raizen, and C. Fang-Yen, “Quantitative assessment of fat levels in Caenorhabditis elegans using dark field microscopyG3 (Genes Genomics Genetics) 7: 1811-1818 (2017)
  7. R. J. McCloskey, A. D. Fouad, M. A. Churgin, and C. Fang-Yen, “Food Responsiveness Regulates Episodic Behavioral States in Caenorhabditis elegans”, Journal of Neurophysiology  117, 1911-1934 (2017)
  8. M. Ianaconne, I. Beets, M. D. Nelson, M. Churgin, C. Fang-Yen, L. Schoofs, and D. M. Raizen, “The RFamide receptor DMSR-1 regulates stress-induced sleep in C. elegans”, eLife 6, e19837 (2017)
  9. N. Trojanowski, D. M. Raizen, and C. Fang-Yen, “Pharyngeal pumping in Caenorhabditis elegans depends on tonic and phasic signaling from the nervous system”, Scientific Reports 6, 22940 (2016)
  10. M. A. Churgin and C. Fang-Yen, “An imaging system for C. elegans behavior”, in C. elegans, Methods and Applications, G. Haspel and D. Biron, eds., Methods in Molecular Biology 1327: 199-207 (2015)
  11. N. Trojanowski and C. Fang-Yen, “Simultaneous Optogenetic Stimulation of Individual Pharyngeal Neurons and Monitoring of Feeding Behavior in Intact C. elegans”, in C. elegans, Methods and Applications, G. Haspel and D. Biron, eds., Methods in Molecular Biology Vol. 1327: 105-119 (2015)
  12. S. Bais, M. A. Churgin, C. Fang-Yen, and R. M. Greenberg, “Evidence for novel pharmacological sensitivities of transient receptor potential (TRP) channels in Schistosoma mansoni”, PLoS Neglected Tropical Diseases (2015)
  13. N. Trojanowski, M. D. Nelson, S. Flavell, C. Fang-Yen, and D. M. Raizen, “Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States”, Journal of Neuroscience 35(43): 14571-14584 (2015)
  14. Q. J. Han, W. R. T. Witschey, C. Fang-Yen, J. Arkles, A. J. Barker, P. R. Forfia, and Y. Han, “Altered right ventricular kinetic energy work density and viscous energy dissipation in patients with pulmonary arterial hypertension: a pilot study using 4D Flow MRI”, PLoS ONE 10(9):e0138365 (2015)
  15. Choi, M. Kim, D. Kim, C. Yoon, C. Fang-Yen, Q. Park, W. Choi, "Preferential coupling of an incident wave to reflection eigenchannels of disordered media", Scientific Reports 5, 11393 (2015)
  16. M. D. Nelson, K. H. Lee, M. A. Churgin, A. Hill, C. V. Buskirk, C. Fang-Yen and D. M. Raizen, "FMRF-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans", Current Biology 24, 2406–2410 (2014)
  17. N. Trojanowski, O. Padovan-Merhar, D. M. Raizen, and C. Fang-Yen, “Neural and genetic degeneracy underlies Caenorhabditis elegans feeding behavior”, Journal of Neurophysiology 112, 951-961 (2014) [ link ]
  18. M. A. Churgin, L. He, J. I. Murray, and C. Fang-Yen, “Construction of a system for single-cell transgene induction in Caenorhabditis elegans using a pulsed infrared laser”, Methods 68, 431-436 (2014)
  19. C. C. Yu, D. M. Raizen, and C. Fang-Yen, "Multi-well Imaging of Development and Behavior in Caenorhabditis elegans", Journal of Neuroscience Methods 223, 35-39 (2014) [Movie 1] [Movie 2]
  20. M. D. Nelson, N. F. Trojanowski, J. B. George-Raizen, C. J. Smith, C. C. Yu, C. Fang-Yen, and D. M. Raizen, "The neuropeptide NLP-22 regulates a sleep-like state in Caenorhabditis elegans", Nature Communications 4:2846 (2013)
  21. M. A. Churgin, L. He, J. I. Murray, and C. Fang-Yen, "Efficient single-cell transgene induction in Caenorhabditis elegans using a pulsed infrared laser", G3 (Genes Genomics Genetics) 3: 1827-1832 (2013) [Suppl. Info] [cover image]
  22. E. Kim, L. Sun, C. V. Gabel, and C. Fang-Yen, "Long-term imaging of Caenorhabditis elegans using nanoparticle-mediated immobilization", PLoS ONE 8, e53419 (2013)
  23. Q. Wen, M. Po, E. Hulme, S. Chen, X. Liu, S. Kwok, M. Gershow, A. M. Leifer, V. Butler, C. Fang-Yen, T. Kawano, W. R. Schafer, G. Whitesides, M. Wyart, D. B. Chklovskii, M. Zhen, and A. D. T. Samuel, “Proprioceptive Coupling within Motor Neurons Drives C. elegans Forward Locomotion, Neuron 76, 750–761 (2012)
  24. L. Emtage, S. Aziz-Zaman, O. Padovan-Merhar, H. R. Horvitz, C. Fang-Yen, and N. Ringstad, "IRK-1 potassium channels mediate peptidergic inhibition of C. elegans serotonin neurons via a Go signaling pathway", Journal of Neuroscience  32, 16285–16295 (2012)
  25. Y. Choi, C. Yoon, M. Kim, T. D. Yang, C. Fang-Yen, R. R. Dasari, K. J. Lee, and W. Choi, "Scanner-free and wide-field endoscopic imaging using a single multimode optical fiber", Physical Review Letters 109, 203901 (2012)
  26. S. Oh, C. Fang-Yen, W. Choi, Z. Yaqoob, D. Fu , Y. Park, R. R. Dasari, M. S. Feld, "Label-free Imaging of Membrane Potential using Membrane Electromotility", Biophysical Journal 103, 11-18 (2012)  [Suppl. Info PDF]
  27. M. Kim , Y. Choi , C. Fang-Yen , Y. Sung , K. Kim , R. R. Dasari , M. S. Feld, and W. Choi, "3D differential interference contrast microscopy using synthetic aperture imaging", Journal of Biomedical Optics 17, 026003 (2012)
  28. A. M. Leifer*, C. Fang-Yen*, M. Gershow, M. J. Alkema, and A. D. T. Samuel, “Optogenetic manipulation of neural activity with high spatial resolution in freely moving Caenorhabditis elegans, Nature Methods 8, 147–152 (2011) [ Movies, software ] *equal contributions
  29. Y. Choi, T. D. Yang, C. Fang-Yen, P. Kang, K. J. Lee, R. R. Dasari, M. S. Feld, and W. Choi, "Overcoming the diffraction limit using multiple light scattering in a highly disordered medium", Physical Review Letters 107, 023902 (2011)
  30. C. Fang-Yen, W. Choi, Y. Sung, C. J. Holbrow, R. R. Dasari, and M. S. Feld, "Video-rate tomographic phase microscopy", Journal of Biomedical Optics 16, 011005 (2011) [Movie 1] [Movie 2]
  31. M. Kim, Y. Choi, C. Fang-Yen, Y. Sung, R. R. Dasari, M. S. Feld, and W. Choi, "High-speed synthetic aperture microscopy for live cell imaging", Optics Letters 36, 148-150 (2011)
  32. H. Ha, M. Hendricks, Y. Shen, C. V. Gabel, C. Fang-Yen, Y. Qin, D. Colon-Ramos, K. Shen, A. D. T. Samuel, and Y. Zhang, "Functional Organization of a Neural Network for Aversive Olfactory Learning in Caenorhabditis elegans, Neuron 68, 1173-1186 (2010)
  33. C. Fang-Yen, M. Wyart, J. Xie, R. Kawai, S. Chen, T. Kodger, Q. Wen, and A. D. T. Samuel, “Biomechanical analysis of gait adaptation in the nematode Caenorhabditis elegans”, Proceedings of the National Academy of Sciences USA 107, 20323-20328 (2010) [ Supp. Info PDF ] [  Movie1 ] [ Movie2 ] [ Movie3 ] [ Movie4 ] [ Movie5 ]
  34. L. Luo, M. Gershow, M. Rosenzweig, K. Kang, C. Fang-Yen, P. Garrity, and A. D. T. Samuel, "Navigational decision-making in Drosophila thermotaxis", Journal of Neuroscience 30, 4261-4272 (2010)
  35. W. Seo, H. Hong, M. Lee, Y. Song, Y. Chough, W. Choi, C. Fang-Yen, R. R. Dasari, M. S. Feld, J. Lee, and K. An, "Realization of a bipolar atomic Solc filter in the cavity-QED microlaser", Physical Review A 81, 053824 (2010)
  36. C. Fang-Yen, L. Avery, and A. D. T. Samuel, "Two size-selective mechanisms specifically trap bacteria-sized food particles in Caenorhabditis elegans" Proceedings of the National Academy of Sciences USA 106, 20093-20096 (2009) [ Supp. Info PDF ] [ Movies ]
  37. Z. Yaqoob, W. Choi, S. Oh, N. Lue, Y. Park, C. Fang-Yen, R. R. Dasari, K. Badizadegan, and M. S. Feld, "Improved phase sensitivity in spectral domain phase microscopy using line-field illumination and self phase-referencing" Optics Express 17, 10681-10687 (2009)
  38. Y. Sung, W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Optical diffraction tomography for high resolution live cell imaging", Optics Express 17, 266-277 (2009)
  39. H. Hong, W. Seo, M. Lee, Y. Song, W. Choi, C. Fang-Yen, R. R. Dasari, M. S. Feld, J. Lee, and K. An, "Effects of coupled bichromatic atom-cavity interaction in the cavity-QED microlaser", Physical Review A 79, 033816 (2009)
  40. M. Zhang, S. H. Chung, C. Fang-Yen, C. Craig, R. A. Kerr, H. Suzuki, A. D. T. Samuel, E. Mazur, and W. R. Schafer, "A Self-Regulating Feed-Forward Circuit Controlling C. elegans Egg-Laying Behavior", Current Biology 18, 1445-1455 (2008)
  41. W. Choi, C. C. Yu, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Field-based angle-resolved light scattering study of single live cells", Optics Letters 33, 1596-1598 (2008)
  42. W. Choi, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Extended depth of focus in tomographic phase microscopy using a propagation algorithm", Optics Letters 33, 171-173 (2008)
  43. C. Fang-Yen, M. Chu, H. S. Seung, R. R. Dasari, and M. S. Feld, "Phase-referenced probe interferometer for biological surface profiling and displacement measurements", Review of Scientific Instruments 78, 123703 (2007)
  44. W. Choi, C. Fang-Yen, K. Badizadegan, S. Oh, N. Lue, R. R. Dasari, and M. S. Feld, "Tomographic Phase Microscopy", Nature Methods 4, 717-719 (2007)
  45. C. Fang-Yen, S. Oh, Y. Park, W. Choi, S. Song, H. S. Seung, R. R. Dasari, M. S. Feld, "Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy", Optics Letters 32, 1572-1574 (2007)
  46. C. C. Yu, C. Lau, J. Tunnell, M. Hunter, M. Kalashnikov, C. Fang-Yen, S. Fulghum, K. Badizadegan, R. Dasari, and M. S. Feld, "Assessing Epithelial Cell Nuclear Morphology using Azimuthal Light Scattering Spectroscopy", Optics Letters 31, 3119-3121 (2006)
  47. C. Fang-Yen, "Quantum trajectory studies of many-atom and finite transit-time effects in a cavity QED microlaser or micromaser", Optics Communications 262, 224-228 (2006)
  48. C. Fang-Yen, C. C. Yu, S. Ha, W. Choi, K. An, R. R. Dasari, and M. S. Feld, "Observation of Multiple Thresholds in the Cavity QED Microlaser", Physical Review A (Rapid Communications) 73, 041802 (2006)
  49. W. Choi, C. Fang-Yen, J. Lee, K. An, R. R. Dasari, and M. S. Feld, "Observation of Nonclassical Photon Statistics in the Cavity QED Microlaser", Physical Review Letters 96, 093603 (2006)
  50. A. Ahn, C. Yang, A. Wax, G. Popescu, C. Fang-Yen, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Harmonic phase dispersion microscope with a Mach-Zehnder interferometer", Applied Optics 44, 1188 (2005)
  51. W. Choi, M. Lee, Y. Lee, C. Park, J. Lee, K. An, C. Fang-Yen, R. R. Dasari, and M. S. Feld, "Calibration of second-order correlation functions for non-stationary sources with a multi-start multi-stop time-to-digital converter", Review of Scientific Instruments 76, 083109 (2005)
  52. C. Fang-Yen, M. Chu, H. S. Seung, R. R. Dasari, and M. S. Feld, "Non-contact measurement of nerve displacement during action potential with a dual-beam low coherence interferometer", Optics Letters 17, 2028 (2004)
  53. H. Iwai, C. Fang-Yen, G. Popescu, K. Badizadegan, R. R. Dasari, and M. S. Feld, "Quantitative phase imaging using actively stabilized phase shifting low-coherence interferometry", Optics Letters 29, 2399 (2004)
  54. K. An, B. A. Sones, C. Fang-Yen, R. R. Dasari, and M. S. Feld, "Optical bistability induced by mirror absorption: measurement of absorption coefficients in sub-ppm level", Optics Letters 22, pp. 1433-1435 (1997)
  55. C. Fang-Yen, M.I. Dykman, and M.J. Lea, "Internal forces in nondegenerate 2D electron systems", Physical Review B 55, pp. 16272-79 (1997)
  56. M.I. Dykman, C. Fang-Yen, and M.J. Lea, "Many-electron transport in strongly correlated nondegenerate 2D electron systems", Physical Review B 55, pp. 16249-71 (1997)
  57. M.J. Lea, P. Fozooni, A. Kristensen, P.J. Richardson, K. Djerfi, A. Santrich-Badal, M.I. Dykman, C. Fang-Yen, and A. Blackburn, "Magnetoconductivity of two-dimensional electrons on liquid helium: Experiments in the fluid phase", Physical Review B 55 , pp. 16280 - 92 (1997).
  58. P. Fozooni, P.J. Richardson, M.J. Lea M.I. Dykman, C. Fang-Yen, and A. Blackburn, "Internal Forces and the Magnetoconductivity of a Nondegenerate 2D Electron Fluid", Journal of Physics C: Condensed Matter 8, L215 - L221 (1996).
  59. M.J. Lea, K. Djerfi, P. Fozooni, A. Kristensen, A. Santrich-Badal, A. Blackburn, M.I. Dykman, C. Fang-Yen, and P.J. Richardson, "Many-electron magnetoconductivity in 2D electrons on liquid helium", Surface Science 361-362, p. 835 - 838 (1996).

Review Articles and Book Chapters

  1. W. Luyten, P. Antal, B. P. Braeckman, J. Bundy, F. Cirulli, C. Fang-Yen, G. Fuellen, A. Leroi, Q. Liu, P. Martorell, A. Metspalu, M. Perola, M. Ristow, N. Saul, L. Schoofs, K. Siems, L. Temmerman, S. Van Vooren, A. Wolk and S. I. S. Rattan, “Ageing with elegans: a research proposal to map healthspan pathways”, Biogerontology 17(4): 771-82 (2016)
  2. C. Fang-Yen, M. Alkema, and A. D. T. Samuel, “Illuminating neural circuits and behavior in Caenorhabditis elegans with optogenetics”, Philosophical Transactions of the Royal Society B  370(1677), 20140212 (2015)
  3. C. Fang-Yen, C. V. Gabel, A. D. T. Samuel, C. I. Bargmann, and L. Avery, "Laser microsurgery in Caenorhabditis elegans" in Caenorhabditis elegans: Cell Biology and Physiology, 2nd edition, Joel H. Rothman and Andrew Singson, eds.: Methods in Cell Biology, Vol 107, Elsevier Academic Press, p. 177-206 (2012)
  4. C. Fang-Yen and M. S. Feld, "Intrinsic optical signals in neural tissues: measurements, mechanisms, and applications", in New Approaches in Biomedical Spectroscopy, K. Kneipp, R. Aroca, H. Kneipp, E. Wentrup-Byrne, eds., Oxford University Press (2007)


Other publications
  1. C. Fang-Yen, S. Wasserman, P. Sengupta, and A. D. T. Samuel, "Agarose immobilization of C. elegans", Worm Breeder's Gazette 18, 32 (2009)
  2. G. Popescu, C. Fang-Yen, L. Deflores, M. Chu, H. Iwai, M. Hunter, M. Kalashnikov, V. Backman, K. Badizadegan, C. Boone, G. Stoner, R. R. Dasari and M. S. Feld, "Seeing Small Biological Structures with Light", in Laser Spectroscopy - Proceedings of the XVI International Conference (ICOLS 2003), P. Hannaford, A. Sidorov, H. Bachor, and K. Baldwin eds., (World Scientific Publishing, Singapore) p. 375-382 (2003),
  3. C. Fang-Yen, "Multiple Thresholds and Many-Atom Dynamics in the Cavity QED Microlaser", Ph. D. thesis, Massachusetts Institute of Technology (2002).
  4. C.-C. Yu, C. Fang-Yen, A. Aljalal, R. R. Dasari, K. An, and M. S. Feld, "Single-Atom Lasers", in McGraw-Hill Yearbook of Science & Technology 2001 (McGraw-Hill, New York, 2001)
  5. A. Blackburn, K. Djerfi, M.I. Dykman, C. Fang-Yen, P. Fozooni, A. Kristensen, M.J. Lea, P.J. Richardson, A. Santrich-Badal, and R.W. van der Heijden, "Magnetotransport of 2D electrons on liquid helium in the fluid and solid phases", Czech. J. of Phys. 46 p. 3056 - 3062 Suppl. S6 (1996). (Invited papers of the International Conference on Low Temperature Physics LT-XXI)
  6. P.J. Richardson, K. Djerfi, P. Fozooni, M.J. Lea, A. Santrich-Badal, M.I. Dykman, C. Fang-Yen, and A. Blackburn, "Many-electron magnetoconductivity of 2D electrons on liquid helium", Czech. J. Phys. 46, p. 329-330 Suppl. 1 (1996). (Invited papers of the International Conference on Low Temperature Physics LT-XXI)